It was first made by Union Chimique Belge in and was approved for sale by Pfizer in the United States later that year.
Generic alternatives may be available.
What special precautions should I follow?
See also: Atarax drug interactions in more detail.
The T max of hydroxyzine is about 2.
Cetirizine, although less sedating, is non- dialyzable and possesses similar anti-histaminergic properties.
Use effective birth control, and tell your doctor if you become pregnant during treatment.
Hydroxyzine should be administered carefully in the elderly with consideration given to possible reduced elimination.
Do not let anyone else take your medication.
This list is not complete and other drugs may interact with hydroxyzine.
Be sure to mention any of the following: antihistamines; azithromycin Zithromax, ZMax , certain antidepressants such as citalopram Celexa and fluoxetine Prozac, Sarafem, Selfemra ; medications for anxiety; certain medications for arrhythmias such as amiodarone Cordarone, Nexterone, Pacerone, , procainamide, quinidine in Nuedexta , and sotalol Betapace, Sorine, Sotylize ; barbiturates; clarithromycin Biaxin, in Prevpac ; droperidol Inapsine ; erythromycin Eryc, Ery-Tab, PCE, others ; gatifloxacin; certain medications for mental illness such as chlorpromazine, clozapine Clozaril, Fazaclo ODT, Versacloz , iloperidone Fanapt , quetiapine Seroquel , and ziprasidone Geodon ; meperidine Demerol ; methadone Dolophine, Methadose ; moxifloxacin Avelox ; medications for pain; ondansetron Zofran, Zuplenz ; pentamidine Nebupent, Pentam ; and medications for seizures, sedatives, sleeping pills, and tranquilizers.
In a comparative study with lorazepam on memory effects, patients who had taken hydroxyzine experienced sedative effects like drowsiness, but recalled that they felt capable, attentive and able to continue with a memory test under these conditions.
Irish Medicines Board.
Talk to your doctor before breastfeeding while using this medicine.
Oxford [Oxfordshire]: Oxford University Press.
It is also used together with other medications given for anesthesia.
Analogues of hydroxyzine include buclizine , cetirizine , cinnarizine , cyclizine , etodroxizine , meclizine , and pipoxizine among others.
Oral: 50 to mg orally 4 times a day Parenteral: 50 to mg IM immediately, then every 4 to 6 hours as needed Comments : -Use should be periodically reassessed.
Hydroxyzine may be used to treat allergic skin reactions such as hives or contact dermatitis.
See also: Hydroxyzine side effects in more detail.
It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
Oral: 25 mg orally 3 to 4 times a day Use: Management of pruritus due to histamine-mediated pruritus and allergic conditions e.
However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.
Atypical antipsychotics Olanzapine Quetiapine Risperidone , etc.
Talk to you doctor before using hydroxyzine if pregnant or breastfeeding.
Gabapentin Gabapentin enacarbil Mirogabalin Phenibut Pregabalin.
It also acts as an antihistamine that reduces the natural chemical histamine in the body.
Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine , etc.
Hydroxyzine exhibits anxiolytic and sedative properties in many psychiatric patients.
Since hydroxyzine also reduces activity in the central nervous system, it can be used as a sedative to treat anxiety and tension.
Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
Hydroxyzine side effects in more detail.
From Wikipedia, the free encyclopedia.
In other cases, the usage of hydroxyzine is as a form of non-barbiturate tranquilizer [12] used in the pre-operative sedation and treatment of neurological disorders, such as psychoneurosis and other forms of anxiety or tension states.
Hydroxyzine Dosage Medically reviewed by Drugs.
Higher concentrations are found in the skin than in the plasma.
Hydroxyzine was found to have no adverse effects on memory in relation to lorazepam , which caused several deficiencies in the capacity of memory storage.
Somnolence with or without vivid dreams or nightmares may occur in users with antihistamine sensitivities in combination with other CNS depressants.
Tell your doctor about all your current medicines and any you start or stop using.
Stop using Atarax and call your doctor at once if you have a serious side effect such as tremors, confusion, seizures, or restless muscle movements in your eyes, tongue, jaw, or neck.
Do not take in larger or smaller amounts or for longer than recommended.
This is not a complete list of side effects and others may occur.
Tell your doctor if any of these symptoms are severe or do not go away: dry mouth constipation especially in older adults confusion especially in older adults dizziness headache Some side effects can be serious.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with this medicine.
Hydroxyzine may cause other side effects.
Do not drive a car or operate machinery until you know how this medication affects you.
See also: Atarax dosage information in more detail.
Patient Advice : -Inform patients that this drug may cause drowsiness, and they should avoid driving or operating machinery if these side effects occur.
Do not breastfeed while taking hydroxyzine.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
IUPAC name.
Use of hydroxyzine for premedication as a sedative has no effects on tropane alkaloids, such as atropine , but may, following general anesthesia, potentiate meperidine and barbiturates , and use in pre-anesthetic adjunctive therapy should be modified depending upon the state of the individual.
Follow all directions on your prescription label.
Do not take more or less of it or take it more often than prescribed by your doctor.
Do not take extra medicine to make up the missed dose.

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Measure Atarax syrup with a special dose-measuring spoon or cup, not a regular table spoon.
Serotonin receptor modulators.
To make sure you can safely take Atarax, tell your doctor if you have any of these other conditions:.
While there are reports of the "hallucinogenic" or "hypnotic" properties of hydroxyzine, several clinical data trials have not reported such side effects from the sole consumption of hydroxyzine, but rather, have described its overall calming effect described through the stimulation of areas within the formatio reticularis.
Hydroxyzine can also be used for the treatment of allergic conditions , such as chronic urticaria , atopic or contact dermatoses , and histamine -mediated pruritus.
IV compatibility : -Incompatible: Aminophylline, benzylpenicillin salts, chloramphenicol sodium succinate, dimenhydrinate, doxorubicin hydrochloride in a liposomal formulation , thioridazine, and some soluble barbiturates General : -This drug has demonstrated primary skeletal muscle relaxation and antispasmodic properties experimentally.
Gabapentin Gabapentin enacarbil Phenibut Pregabalin.
Your doctor will probably tell you not to take hydroxyzine.
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Tetracyclic antidepressants Mianserin Mirtazapine , etc.
Other drugs may interact with hydroxyzine, including prescription and over-the-counter medicines, vitamins, and herbal products.
Hydroxyzine is a member of the diphenylmethylpiperazine class of antihistamines.
You should not take this medicine for longer than 4 months.
Do not use Atarax without telling your doctor if you are pregnant.
Do not start a new medication without telling your doctor.
Atropine Diphenhydramine Hydroxyzine very mild Hyoscyamine Scopolamine.
Cerium oxalate Dexamethasone Lorazepam Midazolam Propofol.
It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
Ask your doctor before taking hydroxyzine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all medications you use.
Hydroxyzine can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS.
Get emergency medical help if you have any of these signs of an allergic reaction to Atarax: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Do not use this medicine in larger or smaller amounts or for longer than recommended.
Before Prozac: the troubled history of mood disorders in psychiatry.
Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Hydroxyzine is used in adults and children to relieve itching caused by allergic skin reactions.
Typical antipsychotics Chlorpromazine Thioridazine , etc.
Hydroxyzine dosage information in more detail.